L-DOPA reverses the elevated density of D2 dopamine receptors in Parkinson's diseased striatum
Identifieur interne : 004F17 ( Main/Exploration ); précédent : 004F16; suivant : 004F18L-DOPA reverses the elevated density of D2 dopamine receptors in Parkinson's diseased striatum
Auteurs : M. Guttman [Canada] ; P. Seeman [Canada]Source :
- [ 0300-9564 ]
Abstract
Summary: Striatal dopamine receptors were studied using [3H]-spiperone in postmortem tissues of thirty-six patients with Parkinson's Disease. Each tissue was analyzed by the receptor saturation method. In non-treated patients, the D2 dopamine receptor density was elevated in the caudate nucleus and putamen compared to controls. In L-DOPA-treated patients, the receptor density was the same as controls. The dissociation constant for [3H]-spiperone was similar in all groups. The elevated density of D2 receptors in non-treated patients may indicate dopaminergic supersensitivity in this disease. The elevated density was reversed with dopamine agonist therapy, but the density was not lower than control tissues.
Url:
DOI: 10.1007/BF01245971
Affiliations:
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<record><TEI wicri:istexFullTextTei="no"><teiHeader><fileDesc><titleStmt><title xml:lang="en">L-DOPA reverses the elevated density of D2 dopamine receptors in Parkinson's diseased striatum</title><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></author><author><name sortKey="Seeman, P" sort="Seeman, P" uniqKey="Seeman P" first="P." last="Seeman">P. Seeman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:04E8D7AD78A1690D56740B63DCF78E9AB756DDEB</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1007/BF01245971</idno><idno type="url">https://api-v5.istex.fr/document/04E8D7AD78A1690D56740B63DCF78E9AB756DDEB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000291</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000291</idno><idno type="wicri:Area/Istex/Curation">000291</idno><idno type="wicri:Area/Istex/Checkpoint">002489</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002489</idno><idno type="wicri:doubleKey">0300-9564:1985:Guttman M:l:dopa:reverses</idno><idno type="wicri:Area/Main/Merge">005928</idno><idno type="wicri:Area/Main/Curation">004F17</idno><idno type="wicri:Area/Main/Exploration">004F17</idno></publicationStmt><sourceDesc><biblStruct><analytic><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Toronto, Medical Sciences Building, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Seeman, P" sort="Seeman, P" uniqKey="Seeman P" first="P." last="Seeman">P. Seeman</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><idno type="ISSN">0300-9564</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Striatal dopamine receptors were studied using [3H]-spiperone in postmortem tissues of thirty-six patients with Parkinson's Disease. Each tissue was analyzed by the receptor saturation method. In non-treated patients, the D2 dopamine receptor density was elevated in the caudate nucleus and putamen compared to controls. In L-DOPA-treated patients, the receptor density was the same as controls. The dissociation constant for [3H]-spiperone was similar in all groups. The elevated density of D2 receptors in non-treated patients may indicate dopaminergic supersensitivity in this disease. The elevated density was reversed with dopamine agonist therapy, but the density was not lower than control tissues.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></region><name sortKey="Seeman, P" sort="Seeman, P" uniqKey="Seeman P" first="P." last="Seeman">P. Seeman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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